CA Hypopharynx

Cancers of the oropharynx and hypopharynx, HPV-independent click to access explanations in the original CAP template

** Please also refer to H&N biomarker protocol (HeadNeckBiomarkers 2.3.0.0, Apr-2026) for possible ancillary testings.

** If HPV is positive, please consider using the HPV-associated oropharynx cancer protocol.

Microscopic descriptions:

- Tumor histology and immunohistochemical studies:

- Oropharynx CA (WHO 5e) :
- Hypopharynx CA (WHO 5e) :
- Neuroendocrine carcinoma (WHO 5e):
- Other histologic type:
- Histologic grade:
- Tumor extent:
- Lymphatic and/or vascular invasion:
- Perineural invasion:
- HPV status by p16 IHC:
- HPV PCR-Sanger Seq:
- EBER ISH:

** If HPV is positive, please consider using the HPV-associated oropharynx cancer protocol.

Surgical margins of excision specimen:

- Invasive Tumor:
- Noninvasive Tumor:
- Tumor bed margin :

** Please also refer to additional specimens and frozen sections for margin status.

Lymph nodes examination:

- Number of regional lymph nodes examined:
- Number of lymph nodes involved:
- Extranodal extension (ENE) :
- Size of largest metastatic deposit (mm), specify site:
- Size of largest lymph node involved (mm), specify site:
- Laterality:

** Please include also intraparotid and periparotid lymph nodes, in addition to the lymph nodes of the neck dissections.

Distant Metastasis: Not applicable Not identified Non-regional lymph node(s) (specify): Lung (specify): Liver (specify): Bone (specify): Brain (specify): Other (specify): Cannot be determined:

Pathologic Stage Classification (AJCC 8e):

+ Modified classification:	r (recurrent) y (post-neoadjuvant therapy)
- HPV-independent oropharynx (pT)
- Hypopharynx (pT)
+ T-suffix:	m (multiple primary tumors)
- Regional lymph nodes (pN):
- Distant metastasis (pM):

- Additional notes: