HPV-oropharynx CA

HPV-associated SCC of the Oropharynx click to access explanations in the original CAP template

** Please also refer to H&N biomarker protocol (HeadNeckBiomarkers 2.3.0.0, Apr-2026) for possible ancillary testings.

** If HPV is negative, please consider using the HPV-independent oropharynx and hypopharynx cancers protocol.

Microscopic descriptions:

- Tumor histology and immunohistochemical studies:

- Histologic type:
- Tumor extent:
- Lymphatic and/or vascular invasion:
- Perineural invasion:
- HPV status by p16 IHC:
- HPV PCR:

Surgical margins:

- Invasive Tumor:
- Tumor bed margin :

** Please also refer to additional specimens and frozen sections for margin status.

Lymph nodes examination:

- Number of regional lymph nodes examined:
- Number of lymph nodes involved:
- Extranodal extension (ENE) :
- Size of largest metastatic deposit (mm), specify site:
- Size of largest lymph node involved (mm), specify site:
- Laterality:

** Please include also intraparotid and periparotid lymph nodes, in addition to the lymph nodes of the neck dissections.

Distant Metastasis: Not applicable Not identified Non-regional lymph node(s) (specify): Lung (specify): Liver (specify): Bone (specify): Brain (specify): Other (specify): Cannot be determined:

Pathologic Stage Classification (AJCC 9e):

+ Modified classification:	r (recurrent) y (post treatment)
- Primary tumor (pT):
+ T-suffix:	m (multiple primary tumors)
- Regional lymph nodes (pN):
- Distant metastasis (pM):

pT1: Tumor is less than or equal to 2 cm in greatest dimension
pT2: Tumor greater than 2 cm but less than or equal to 4 cm in greatest dimension
pT3: Tumor is greater than 4 cm in greatest dimension or extension to lingual surface of epiglottis
pT4: Tumor invades any of the following: larynx; OR deep / extrinsic muscle of the tongue (genioglossus, hypoglossus, palatoglossus, and styloglossus); OR pterygoid muscles (medial and / or lateral); OR hard palate; OR mandible; OR pterygoid plates (medial and / or lateral); OR nasopharynx; OR skull base; OR encases carotid artery.

- Additional notes: