Bone Tumors

Bone tumors click to access explanations in the original CAP template

This is additional protocol for biopsy specimen of bone tumours.

Microscopic descriptions:

- Tumor histology and immunohistochemical studies:

Chondrogenic Tumors	Synovial chondromatosis Atypical cartilaginous tumor Chondrosarcoma Chondrosarcoma, secondary (specify): Dedifferentiated chondrosarcoma Periosteal chondrosarcoma Clear cell chondrosarcoma Mesenchymal chondrosarcoma
Osteogenic Tumors	Osteoblastoma Low-grade central osteosarcoma Low-grade central osteosarcoma with high-grade transformation Parosteal osteosarcoma Parosteal osteosarcoma with high-grade transformation Conventional osteosarcoma Telangiectatic osteosarcoma Small cell osteosarcoma Periosteal osteosarcoma High-grade surface osteosarcoma Secondary osteosarcoma +Precipitating Factor for Secondary Osteosarcoma:
Undifferentiated Small Round Cell Sarcomas	Ewing sarcoma Round cell sarcoma with EWSR1::non ETS fusions (specify fusion): CIC-rearranged sarcoma Sarcoma with BCOR genetic alterations
Fibrogenic / fibrohistiocytic / histiocytic tumors	Sclerosing epithelioid fibrosarcoma Primary malignant giant cell tumor of bone Secondary malignant giant cell tumor of bone Giant cell tumor of bone Langerhans cell histiocytosis Langerhans cell histiocytosis + single/multisystem or other: Desmoplastic fibroma
Notochordal Tumors	Conventional chordoma Poorly differentiated chordoma Dedifferentiated chordoma
Vascular Tumors	Epithelioid hemangioma Pseudomyogenic hemangioendothelioma Epithelioid hemangioendothelioma Angiosarcoma
Epithelial tumors	Adamantinoma of long bones Osteofibrous dysplasia-like adamantinoma Dedifferentiated adamantinoma
Other mesenchymal tumors or tumors of uncertain differentiation	Leiomyosarcoma of bone Rhabdomyosarcoma of bone (specify fusion): TK-fusion (NTRK, ALK, BRAF) tumor, primary intraosseous (specify fusion): Undifferentiated pleomorphic sarcoma

- Histologic type:
+ Mitotic rate (per 10 traditional HPF or per mm2):
- Necrosis in the Absence of Neoadjuvant Therapy:
- Histologic grade:
- Treatment effect:
- Lymphatic and / or Vascular Invasion:
+ Perineural invasion:

- Using 22 mm eyepiece & 40x objective, count 10 most active fields and divide by 1.373, approximating 10 traditional high power fields of 10 x 0.1734 mm².

- Description of treatment effect: geographic necrosis, fibrosis, hyalinization, hemorrhage, cystic change, histiocytic response, inflammation or others

Surgical margins of excision specimen:

- Surgical margin:

Regional lymph nodes:

- Number of regional lymph nodes examined:
- Number of lymph nodes involved:
- Extranodal extension:
- Size of largest metastatic deposit (mm), specify site:
- Size of largest lymph node involved (mm), specify site:

Distant Metastasis: Not applicable Not identified Non-regional lymph node(s) (specify): Lung (specify): Bone (specify): Other (specify): Cannot be determined:

Pathologic stage classification (AJCC 8e):

- TNM Descriptors:	m (multiple primary tumors) r (recurrent) y (post treatment)
- Primary tumor (pT) (Appendicular Skeleton, Trunk, Skull, and Facial Bones):
- Primary tumor (pT) (Spine):
- Primary tumor (pT) (Pelvis):
- Regional lymph nodes (pN):
- Distant metastasis (pM):

Additional pathologic findings:

+ Preresection treatment:	No known preresection therapy Chemotherapy performed Radiation therapy performed Therapy performed, type not specified Not specified
+ Other (specify):

- Additional notes: