Primary carcinoma of the vagina

Primary Carcinoma of the Vagina click to access explanations in the original CAP template

This is additional protocol for biopsy specimen of vagina.

Microscopic descriptions:

- Tumor histology and immunohistochemical studies:

- Histologic type:
- Histologic grade:
- Other tissue/ organ involvement:	Not applicable Not identified Paravaginal tissues Pelvic sidewall Vagina, lower third Bladder mucosa Rectal mucosa Other organs/tissue (specify): Cannot be determined (explain):
- Lymphovascular invasion:
+ Perineural invasion:
+ p16 IHC:
+ p53 IHC:

HPV-ISH is not available, PCR-sequencing type test can be ordered.

Surgical margins:

- Peripheral margins:
- Deep margins:

Regional lymph nodes:

- Number of regional lymph nodes examined:
- Number of lymph nodes with frank metastasis:
- Number of lymph nodes with isolated tumor cells (0.2 mm or less):
- Size of largest metastatic deposit (mm), specify site:
- Size of largest lymph node involved (mm), specify site:
- Additional lymph node findings:	Extranodal extension Fixed/ulcerated nodes Other (specify): Cannot be determined

Distant Metastasis: Not applicable Not identified Specify: Cannot be determined:

FIGO stage (2018 Cancer Report):

I: Carcinoma is limited to the vaginal wall. It has not spread to nearby lymph nodes (N0) or to distant
sites (M0)

II: Carcinoma has involved the para-vaginal tissue but has not extended to the pelvic wall. It has not
spread to nearby lymph nodes (N0) or to distant sites (M0)

III: Carcinoma has extended to the pelvic wall and/or involving the lower third of the vagina and/or
causing hydronephrosis or nonfunctioning kidney or T1-T3 tumor that has also spread to nearby lymph nodes in the pelvis or groin (inguinal) area (N1) but not distant sites

IV: Carcinoma has extended beyond the true pelvis or has involved the mucosa of the bladder or
rectum (bullous edema as such does not permit a case to be allotted to stage IV)

- IVA: Tumor invades bladder and/or rectal mucosa and/or direct extension beyond the true pelvis.
It might or might not have spread to lymph nodes in the pelvis or groin (inguinal area) (Any N).
It has not spread to distant sites (M0)
- IVB: Spread to distant organs (M1). It can be any size and might or might not have grown into
nearby structures or organs (Any T) It might or might not have spread to nearby lymph nodes (Any N)

+ Additional pathologic findings:

Low grade squamous intraepithelial lesion / vaginal intraepithelial neoplasia, grade 1(VaIN 1) High grade squamous intraepithelial lesion / vaginal intraepithelial neoplasia, grade 2 (VaIN 2) High grade squamous intraepithelial lesion / vaginal intraepithelial neoplasia, grade 3 (VaIN 3) Condyloma acuminatum Adenocarcinoma in situ (AIS) Atypical adenosis

- Other (specify):

- Additional notes: