- Tumor histology and immunohistochemical studies:
- Other tissue/ organ involvement: Not applicable Not identified Right ovary Left ovary Ovary (side not specified) Right fallopian tube Left fallopian tube Fallopian tube (side not specified) Vagina Right parametrium Left parametrium Parametrium (side not specified) Pelvic wall Bladder wall Bladder mucosa Rectal wall Bowel mucosa Omentum Other organs/tissue (specify): Cannot be determined (explain):
I: Confined to the uterine corpus and ovary IA: Disease limited to the endometrium OR non-aggressive histological type, i.e., low-grade endometrioid, with invasion of less than half of the myometrium with no or focal lymphovascular space involvement (LVSI) OR good prognosis disease IA1: Non-aggressive histological type limited to an endometrial polyp OR confined to the endometrium IA2: Non-aggressive histological types involving less than half of the myometrium with no or focal LVSI IA3: Low-grade endometrioid carcinomas limited to the uterus and ovary +IAm (POLEmut): POLE mutated endometrial carcinoma, confined to the uterine corpus or with cervical extension, regardless of the degree of LVSI or histological type IB: Non-aggressive histological types with invasion of half or more of the myometrium, and with no or focal LVSI IC: Aggressive histological types limited to a polyp or confined to the endometrium
II: Invasion of cervical stroma without extrauterine extension OR with substantial LVSI OR aggressive histological types with myometrial invasion IIA: Invasion of the cervical stroma of non-aggressive histological types IIB: Substantial LVSI of non-aggressive histological types IIC: Aggressive histological types with any myometrial involvement +IICm (p53abn): p53 abnormal endometrial carcinoma confined to the uterine corpus with any myometrial invasion, with or without cervical invasion, and regardless of the degree of LVSI or histological type
III: Local and / or regional spread of the tumor of any histological subtype IIIA: Invasion of uterine serosa, adnexa, or both by direct extension or metastasis IIIA1: Spread to ovary or fallopian tube (except when meeting stage IA3 criteria) IIIA2: Involvement of uterine subserosa or spread through the uterine serosa IIIB: Metastasis or direct spread to the vagina and / or to the parametria or pelvic peritoneum IIIB1: Metastasis or direct spread to the vagina and / or the parametria IIIB2: Metastasis to the pelvic peritoneum IIIC: Metastasis to pelvic or para-aortic lymph nodes or both IIIC1: Metastasis to the pelvic lymph nodes IIIC1i: Micrometastasis (to pelvic nodes) IIIC1ii: Macrometastasis (to pelvic nodes) IIIC2: Metastasis to para-aortic lymph nodes up to the renal vessels, with or without metastasis to the pelvic lymph nodes IIIC2i: Micrometastasis (to para-aortic lymph nodes up to the renal vessels, with or without metastasis to the pelvic nodes) IIIC2ii: Macrometastasis (to para-aortic lymph nodes up to the renal vessels, with or without metastasis to the pelvic nodes)
IV: Spread to the bladder mucosa and / or intestinal mucosa and / or distant metastasis IVA: Invasion of the bladder mucosa and / or intestine / bowel mucosa IVB: Abdominal peritoneal metastasis beyond the pelvis IVC: Distant metastasis, including metastasis to any extra- or intra-abdominal lymph nodes above the renal vessels, lungs, liver, brain or bone
+FIGO Modified Classification - Not performed - mPOLEmut (POLE mutation) - mMMRd (mismatch repair deficiency) - mNSMP (no specific molecular profile) - mp53abn (p53 abnormal)
Atypical hyperplasia/endometrial intraepithelial neoplasia (EIN)
- Other (specify):
- Additional notes: