GIST

Gastrointestinal stromal tumor click to access explanations in the original CAP template

This is additional protocol for biopsy specimen of GIST.

This is additional protocol for biomarkers of GIST.

GIST might be associated with several syndrome: Carney triad, Carney-Strakatis syndrome, Neurofibromatosis type 1, Familial GIST syndrome, etc.

Microscopic descriptions:

- Tumor histology and immunohistochemical studies:

- Histologic type:
- Histologic grade: Using 22 mm eyepiece at 40x objective, count active proliferative areas for 42 fields (equals 10 mm²), divide by 2 to get mitotic count for 5 mm²
	- Mitotic count:
+ Necrosis:
+ KIT (CD117) IHC:
+ DOG1 IHC:
+ SDHB IHC:
+ Lymphovascular invasion:
+ Perineural invasion:
- Risk assessment (Miettinen and Lasota 2006):
+ Presurgical treatment:
- Treatment effect:

+ Molecular studies for hot spot mutations of KIT, PDGFRA, RAS or BRAF genes are available in our AP molecular pathology lab. Other possible molecular analysis includes SDHA/B/C/D, NF1 and FGFR1 fusion (not available).

Surgical margins:

Regional lymph nodes:

- Number of regional lymph nodes examined:
- Number of lymph nodes involved:
- Extracapsular spread:
- Size of largest metastatic deposit (mm), specify site:
- Size of largest lymph node involved (mm), specify site:

Distant Metastasis: Not applicable Not identified Non-regional lymph node(s) (specify): Liver (specify): Other (specify): Cannot be determined:

Pathologic Stage Classification (AJCC 8e):

- TNM Descriptors:	m (multiple primary tumors) r (recurrent) y (post treatment)
- Primary tumor (pT):
- Regional lymph nodes (pN):
- Distant metastasis (pM):

- Additional notes: