Thyroid cancers

Carcinoma of the thyroid click to access explanations in the original CAP template

Microscopic descriptions:

- Tumor histology and immunohistochemical studies:

- Low-risk follicular cell-derived thyroid neoplasms:
- Follicular carcinoma:
- Invasive encapsulated follicular variant papillary thyroid carcinoma:
- Papillary carcinoma:
- Oncocytic carcinoma of the thyroid:
- High-grade follicular cell-derived differentiated thyroid carcinoma:
- Poorly differentiated thyroid carcinoma:
- Anaplastic follicular cell-derived thyroid carcinoma:
- Other carcinomas:

- Mitotic count (per 2 mm²):
- Ki67 Labeing index:
- Tumor focality:
- Tumor size:
- Tumor necrosis:
- Angionvasion:
- Lymphatic invasion:
+ Perineural invasion:
- Extrathyroidal extension:

Using 22 mm eyepiece at x40 objective, counting 42 fields = 10 mm²
Divide by 5 to get hot spot mitotic count of 2 mm²

The Ki-67 proliferation index reporting is required in all medullary thyroid carcinomas as well as in the medullary thyroid carcinoma component of mixed medullary and follicular cell-derived thyroid carcinomas. The Ki-67 proliferation assessment should follow the IARC / WHO guidelines. Visual estimation based on routine microscopic examination (also known as eyeballing) is not allowed.

Surgical margins of excision specimen:

- Surgical margin:

Lymph nodes examination:

- Number of regional lymph nodes involved at level VI (pretracheal, paratracheal and prelaryngeal/Delphian, perithyroidal (central compartment dissection):
- Number of regional lymph nodes involved at level VII (superior mediastinal lymph nodes):
- Number of regional lymph nodes involved at Right level I:
- Number of regional lymph nodes involved at Right level II:
- Number of regional lymph nodes involved at Right level III:
- Number of regional lymph nodes involved at Right level IV:
- Number of regional lymph nodes involved at Right level V:
- Number of regional lymph nodes involved at Left level I:
- Number of regional lymph nodes involved at Left level II:
- Number of regional lymph nodes involved at Left level III:
- Number of regional lymph nodes involved at Left level IV:
- Number of regional lymph nodes involved at Left level V:
- Number of regional lymph nodes involved, specify group:
- Extranodal extension:
- Size of largest metastatic deposit (mm), specify site:
- Size of largest lymph node involved (mm), specify site:

Distant Metastasis: Not applicable Not identified Non-regional lymph node(s) (specify): Lung (specify): Bone (specify): Other (specify): Cannot be determined:

Pathologic Stage Classification (AJCC 8e):

- TNM Descriptors:	m (multiple primary tumors) r (recurrent) y (post treatment)
- Primary tumor (pT) for all carcinoma, except MTC:
- Primary tumor (pT) for medullary thyroid carcinoma:
- Regional lymph nodes (pN):
- Distant metastasis (pM):

+ Additional pathologic findings:

Adenoma Adenomatoid nodule(s) or nodular follicular disease Diffuse hyperplasia (Graves’ disease) Thyroiditis (specify type): Parathyroid gland(s) present (specify number, location, and findings): C-cell hyperplasia (specify type and focality

- Other (specify):

- Additional notes: