CNS tumors

Tumors of the Brain and Spinal Cord click to access further explanations in the original CAP template

Microscopic descriptions :

Layer 1: Integrated diagnosis (combined tissue-based histological and molecular diagnosis)
Layer 2: Histopathological classification
Layer 3: CNS WHO grade
Layer 4: Molecular Information

Biomarker studies for gliomas:

Molecular Biomarker Testing for the Diagnosis of Diffuse Gliomas: Guideline From the College of American Pathologists in Collaboration With the American Association of Neuropathologists, Association for Molecular Pathology, and Society for Neuro-Oncology
(Brat et al, Arch Pathol Lab Med—Vol 146, May 2022 )

- IDH status:

- IDH1 R132H (IHC):
- IDH1/IDH2 mutation (sequencing):

- IDH mutant:

- ATRX expression (IHC):
- p53 expression (IHC):
- Chr. 1p/19q codeletion (FISH):
- CDKN2A/CDKN2B homozygous deletion (FISH):
+ TERT promoter mutation (sequencing):
- Others, specify:

- IDH wild-type:

- TERT promoter mutation (sequencing):
- Histone H3 K27M (IHC):
- Histone H3 G34W (IHC):
- Histone H3 mutation (sequencing):
- BRAF V600E mutation (sequencing):
- Chr. 7+/10- (FISH):
- EGFR amplification (FISH):
- Others, specify:

- Tumor histology and immunohistochemical studies:

Integrated diagnosis (WHO 2021):

- Adult diffuse gliomas:
- Pediatric-type diffuse low-grade gliomas:
- Pediatric-type diffuse high-grade gliomas:
- Circumscribed astrocytic gliomas:
- Glioneuronal and neuronal tumors:
- Ependymal tumors:
- Choroid plexus tumors:
- Molecularly Defined Medulloblastomas:
- Histologically Defined Medulloblastomas:
- Other CNS embryonal tumors:
- Pineal tumors:
- Cranial and paraspinal nerve tumors:
- Mesenchymal tumors involving the CNS:
- Melanocytic tumors:
- Hematolymphoid tumors involving the CNS:
- Germ cell tumors:
- Tumors of the sellar region:

- Histological type:
- CNS WHO Grade:
+ Treatment effect:

- Additional notes: