Stomach HER2 test
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HER2 gene amplification :
-
HER2 IHC, biopsy :
(> or = 5 cancer cell clusters)
Cannot be determined
Negative for over-expression
Equivocal for over-expression
Positive for over-expression
- Score:
0 Negative (No reactivity or no membranous reactivity in any cancer cell)
1 Negative (Cancer cell cluster, > or = 5 cells) with a faint or barely perceptible membranous reactivity irrespective of percentage of cancer cells positive)
2 Equivocal (Cancer cell cluster, > or = 5 cells, with a weak to moderate complete, basolateral, or lateral membranous reactivity irrespective of percentage of cancer cells positive)
3 Positive (Cancer cell cluster, > or = 5 cells, with a strong complete basolateral, or lateral membranous reactivity irrespective of percentage of cancer cells positive)
-
HER2 IHC, excision
:
(10% cancer cells)
Cannot be determined
Negative for over-expression
Equivocal for over-expression
Positive for over-expression
- Score:
0 Negative (No reactivity or membranous reactivity in < 10% of cancer cells)
1 Negative (Faint or barely perceptible membranous react ivity in > or = 10% of cancer cells; cells are reactive only in part of their membrane)
2 Equivocal (Weak to moderate complete, basolateral or lateral membranous reactivity in > or = 10% of tumor cells)
3 Positive (Strong complete, basolateral or lateral membranous reactivity in > or = 10% of cancer cells)
-
HER2/neu oncoprotein DISH :
HER2 DISH calculator
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Cannot be determined
Negative for HER2 amplification
Positive for HER2 amplification
- Number of tumor cell counted :
- HER2 signals (black) per cell :
- CEP17 signals (red) per cell :
- HER2/CEP17 ratio :
- Other ISH abnormalities:
Aneusomy
Heterogeneous signals
- Fixation time in buffered formalin :
Optimal fixation (6-72 hours)
Prolonged intervals (> 72 hours)
Uncertain
- Additional notes:
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